Osteoarthritis (OA) of the knee is a degenerative condition affecting three knee compartments (lateral, medial, and patella-femoral), typically developing gradually over a span of 10 to 15 years [1,2]. Primarily caused by wear, tear, and progressive loss of articular cartilage, it can also result from infections leading to joint cavity damage, resulting in discomforts such as limited mobility, joint pain, and swelling [3]. Cartilage tissue alterations and damage are common in all joints, with the knee and hip joints being particularly susceptible due to their weight-bearing nature. Knee OA predominantly occurs in individuals aged over 55, with a higher prevalence among those over 65, and it is estimated that by 2050, 130 million individuals globally will be affected. Early detection and treatment are crucial for mitigating the progression of knee OA and enhancing individuals' quality of life [5]. The complexity of diagnosing and treating knee OA lies in its multifaceted nature,